SEMINAR

Collaborative Innovation Center for life and health materials, SICCAS

中国科学院上海硅酸盐研究所生命健康材料协同创新中心

Magnetic nanoprobes for imaging-guided cancer therapy

磁性纳米探针用于影像引导的肿瘤治疗

侯仰龙

北京大学工学院

时间：2020年11月13日（星期五）15:30

地点：长宁园区4号楼14楼第一会议室

欢迎广大科研人员和研究生参加讨论！

联系人：陈航榕 

　　Abstract:  

　　Magnetic nanoparticles are considered to have great potential in biomedical applications due to their intrinsically peculiar magnetic, high efficiency catalytic activity and good biocompatibility. This presentation will focus on the development of magnetic nanoprobes and application in imaging-guided cancer precision therapy in our group recent years. Firstly, we try to utilize the physical properties of magnetic nanoparticles to improve the diagnosis and treatment for cancer. A novel multifunctional probe Fe₅C₂-Z_HER2:342 was designed for magnetic resonance imaging/photoacoustic tomography-guided targeting photothermal therapy.^[1] Furthermore, Fe₅C₂ NPs can also be a remote-controlled platform for photochemothermal cancer therapy by loading anticancer drug doxorubicin. Next we have developed a magnetic nanoprobe based on pH-sensitive Fe₅C₂@Fe₃O₄ nanoparticles for switchable magnetic resonance imaging-guided cancer therapy by reactive oxygen species. To achieve multi-modality imaging, recently, multifunctional heterostructure Au-Fe₂C-Z_HER2:342 were fabricated as a multifunctional nanoprobe for triple-modal magnetic resonance imaging/multispectral photoacoustic tomography/computed tomography-guided photothermal therapy. Moreover, to effectively utilize the ROS effect, we proposed magnetic nanoprobe of near-infrared light and cancer microenvironment dual responsive size-switchable DOX-ICG@Fe/FeO-PPP-FA nanocapsules with PLGA which offers fluorescence imaging/magnetic resonance imaging-guided chemotherapy, photothermal therapy and chemodynamic therapy, particularly, the degradation of PLGA matrix and Fe/FeO NPs was observed, significant phenomenon for further medical applications. In summary, it is expected that magnetic probes are promising platforms which provides imaging-guided therapy triggered from their intrinsic physical properties and the contribution of other counterparts such as targeting molecules and drugs. 

　　报告人简介： 

　　侯仰龙，北京大学博雅特聘教授，皇家化学会会士（FRSC），国家重点研发计划纳米科技专项首席科学家，磁电功能材料与器件北京市重点实验室主任。主要从事多功能磁性材料、新能源材料的控制合成及其在纳米生物医学与能源领域的应用探索研究。发展了单分散磁性纳米材料的通用制备方法，探索了磁性纳米颗粒在肿瘤等重大疾病的诊断与治疗的应用；设计制备了若干纳米结构杂化材料用于高性能的锂电池电极等。迄今发表学术论文180余篇，引用17400余次，H因子69。申请专利14项，授权12项。2019年获国家自然科学二等奖1项。荣获全国创新争先奖状、北京茅以升青年科技奖、中国化学会-英国皇家化学会青年化学奖。曾获国家杰出青年科学基金资助，先后入选教育部长江学者特聘教授、教育部新世纪优秀人才、全国优秀科技工作者和科睿唯安高被引科学家（2018, 2019）。在国际和各类双边会议上作大会或分会邀请报告50余次。正主持国家重点研发计划，国家自然科学基金委重点项目、重大项目课题等。现任Rare Metals副主编，Advanced Science、Science China Materials等期刊编委，中国化学会理事、青年委员会主任委员等。