The State Key Lab of
High Performance Ceramics and Superfine Microstructure
Shanghai Institute of Ceramics, Chinese Academy of Sciences
中 国 科 学 院 上 海 硅 酸 盐 研 究 所 高 性 能 陶 瓷 和 超 微 结 构 国 家 重 点 实 验 室
Cutting Edge Optical Imaging Strategies for Precise Regulation of Cellular Functions and Localized Theranostics
School of Physical and Mathematical Sciences; Nanyang Technological University
Generally, optical imaging including fluorescent and bioluminescent imaging enables such rapid, direct and sensitive visualization, mainly due to their high sensitivity, relative safety, and easily handling, and therefore have become robust and reliable tools in monitoring of subcellular protein dynamics and analysis of tumors or pathogen–host interactions in vitro, in vivo and even in pre-clinical practice. The systematic imaging investigation of biomolecules activities including enzymes or proteins etc in a complicated environment may offer great possibility for the in-depth understanding of the biological basis conferring diseases status, and importantly, for the facilitating of new theranostics in vitro and in vivo. In our group, a series of simple and specific small molecules or nano-structure based optical imaging probes have been extensively established to real-time visualize cellular function and activities, importantly, the intrinsic mechanisms to involve in potent drug activities and relevant pathways to initiate drug resistance have also been well investigated.
Prof. XING received his Ph.D. in Department of Chemistry, Nanjing University in 2000. Then, he worked as research associate in the Hong Kong University of Science and Technology (HKUST) until early of 2003. From 2003 – 2005, he held his Post-Doc. Fellowship at Crump Institute of Molecular Imaging at University of California, Los Angles (UCLA) and Molecular Imaging Program at School of Medicine (MIPS), Stanford University. In Dec.2005, he was appointed as Assistant Professor at NTU and later promoted to Associated Professor in 2011. Currently, Prof. XING is holding appointment of Assistant Chair of School of Physical and Mathematical Sciences.
His current research interests: Biomedical Fluorescent Imaging, Chemical Biology and Pharmaceutical Nano-Biology.
Home page: http://www.ntu.edu.sg/home/bengang/